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1

Mechanisms of Asbestos-induced Nitric Oxide Production by Rat Alveolar Macrophages in Inhalation and in vitro Models

Timothy R Quinlan, Kelly A BeruBe, Miles P Hacker, Douglas J Taatjes, Cynthia R Timblin, Jonathan Goldberg, Priscilla Kimberley, Patrick O’Shaughnessy, David Hemenway, Jennifer Torino, Luis A Jimenez,

Journal:

Free Radical Biology and Medicine

Année:

1998

Langue:

english

Fichier:

PDF, 1.04 MB

english, 1998

2

Nutritional folate deficiency augments the in vivo mutagenic and lymphocytotoxic activities of alkylating agents

Richard F. Branda, Miles Hacker, Amy Lafayette, Elizabeth Nigels, Linda Sullivan, Janice A. Nicklas, J. Patrick O'Neill

Journal:

Environmental and Molecular Mutagenesis

Année:

1998

Langue:

english

Fichier:

PDF, 118 KB

english, 1998

3

ChemInform Abstract: Synthesis and Antitumor Activities of 5-Methyl-1- and 2-[[2-Dimethylaminoethyl]amino]-aza-thiopyranoindazoles.

A. Paul Krapcho, Simon N. Haydar, Starlan Truong-Chiott, Miles P. Hacker, E. Menta, G. Beggiolin

Journal:

Année:

2000

Fichier:

PDF, 30 KB

2000

4

Synthesis of hydroxy-substituted aza-analogues of antitumor anthrapyrazoles

A. Paul Krapcho, Cynthia E. Gallagher, Abdelhakim Hammach, Miles P. Hacker, Ernesto Menta, Ambrogio Oliva, Roberto Di Domenico, Giovanni Da Re, Andrea Lotto, Silvano Spinelli

Journal:

Journal of Heterocyclic Chemistry

Année:

1998

Fichier:

PDF, 1.04 MB

1998

5

Shikimic acid complexes of platinum. Preparation, reactivity, and antitumor activity of (R,R-1,2-diaminocyclohexane) bis(shikimato)platinum(II). Evidence for a novel rearrangement involving platinum—carbon bond formation

Nicholas Farrell, John D. Roberts, Miles P. Hacker, Nicholas Farrell, John D. Roberts, Miles P. Hacker

Journal:

Journal of Inorganic Biochemistry

Année:

1991

Langue:

english

Fichier:

PDF, 717 KB

english, 1991

6

Specific antibody synthesis in vitro. II. Age-associated thymosin enhancement of antitetanus antibody synthesis

William B. Ershler, Ann L. Moore, Miles P. Hacker, James Ninomiya, Paul Naylor, Allan L. Goldstein

Journal:

Immunopharmacology

Année:

1984

Langue:

english

Fichier:

PDF, 792 KB

english, 1984

7

Properties of a chloroquine adduct of rhodium acetate

Nicholas Farrell, Miles P. Hacker

Journal:

Inorganica Chimica Acta

Année:

1989

Langue:

english

Fichier:

PDF, 249 KB

english, 1989

8

Synthesis and antitumor activity of organometallic cis-dichloro(enamine)(amine) platinum(II) complexes

Abdul R. Khokhar, Sheryl L. Doran, David B. Brown, Miles P. Hacker

Journal:

Inorganica Chimica Acta

Année:

1987

Langue:

english

Fichier:

PDF, 227 KB

english, 1987

9

The synthesis and antitumor properties of a series of water soluble carboxylato-( 1,2-diaminocyclohexane) platinum(II) complexes

Abdul R. Khokhar, Irwin H. Krakoff, Miles P. Hacker, John J. McCormack

Journal:

Inorganica Chimica Acta

Année:

1985

Langue:

english

Fichier:

PDF, 380 KB

english, 1985

10

Synthesis and antitumor activity of platinum complexes containing neutral and protonated amino-olefin ligands

David B. Brown, Abdul R. Khokhar, Miles P. Hacker, John J. McCormack, Wayne M. Stalick

Journal:

Inorganica Chimica Acta

Année:

1982

Langue:

english

Fichier:

PDF, 777 KB

english, 1982

11

New biologically active cyclophosphazene derivatives

Christopher W. Allen, John A. MacKay, John J. McCormack, Robert A. Newman, Miles P. Hacker

Journal:

Inorganica Chimica Acta

Année:

1982

Langue:

english

Fichier:

PDF, 169 KB

english, 1982

12

Chemical and biological characterization of a series of water soluble 1,2-diaminocyclohexane platinum(II) complexes

Abdul R. Khokhar, Miles P. Hacker

Journal:

Inorganica Chimica Acta

Année:

1991

Langue:

english

Fichier:

PDF, 364 KB

english, 1991

13

Synthesis and antitumor activities of 5-methyl-1- and 2-[[2-dimethylaminoethyl]amino]-aza-thiopyranoindazoles

A.Paul Krapcho, Simon N. Haydar, Starlan Truong-Chiott, Miles P. Hacker, E. Menta, G. Beggiolin

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2000

Langue:

english

Fichier:

PDF, 134 KB

english, 2000

14

Regional fibrosis after intraperitoneal administration of mafosfamide

John D. Roberts, Robert A. Newman, Priscilla J. Kimberly, Miles P. Hacker

Journal:

Investigational New Drugs

Année:

1986

Langue:

english

Fichier:

PDF, 854 KB

english, 1986

15

Efficacy and toxicity of 4-(2-sulfonatoethylthio)-cyclophosphamide cyclohexylamine salt (ASTA Z 7557, INN mafosfamide) after intraperitoneal administration to mice

John D. Roberts, Miles P. Hacker, Robert A. Newman, John J. McCormack, Irwin H. Krakoff

Journal:

Investigational New Drugs

Année:

1984

Langue:

english

Fichier:

PDF, 1015 KB

english, 1984

16

The effect of disulfiram on cyclophosphamide-mediated myeloid toxicity

Richard L. Gamelli, William B. Ershler, Miles P. Hacker, Roger S. Foster

Journal:

Cancer Chemotherapy and Pharmacology

Année:

1986

Langue:

english

Fichier:

PDF, 343 KB

english, 1986

17

Synthesis and antitumor activity of a series of (aminoethylpyrrolidine) platinum complexes

Abdul R. Khokhar, David B. Brown, John J. McCormack, Miles P. Hacker

Journal:

Cancer Chemotherapy and Pharmacology

Année:

1989

Langue:

english

Fichier:

PDF, 316 KB

english, 1989

18

Prevention of cyclophosphamide-induced haemorrhagic cystitis by disulfiram

William B. Ershler, Miles P. Hacker, Richard Gamelli

Journal:

Annals of Hematology

Année:

1982

Langue:

english

Fichier:

PDF, 58 KB

english, 1982

19

Effect of osmotic diuresis on gentamicin-induced nephrotoxicity in rats

Robert A. Newman, Leonard B. Weinstock, Dieter W. Gump, Miles P. Hacker, Jerome W. Yates

Journal:

Archives of Toxicology

Année:

1980

Langue:

english

Fichier:

PDF, 514 KB

english, 1980

20

Investigations on the mechanisms of methotrexate resistance in a cisplatin-resistant L1210 murine leukemia cell subline

Diana H. Wroblewski, Alok Bhushan, Yongzhi Xuan, Bradford T. Brinton, Thomas R. Tritton, Miles P. Hacker

Journal:

Cancer Chemotherapy and Pharmacology

Année:

1996

Langue:

english

Fichier:

PDF, 354 KB

english, 1996

21

Synthesis and antitumor activity of platinum complexes of protonated diamines

Sheryl L. Doran, Abdul R. Khokhar, Miles P. Hacker

Journal:

Inorganica Chimica Acta

Année:

1985

Langue:

english

Fichier:

PDF, 262 KB

english, 1985

22

Water soluble DACHPt(II) complexes: Problems of purification; Stability of complexes with nitrogen-containing ligands

John D. Roberts, Wendelyn J. Schmidt, William P. Tong, Miles P. Hacker

Journal:

Inorganica Chimica Acta

Année:

1988

Langue:

english

Fichier:

PDF, 464 KB

english, 1988

23

Vasoactive Intestinal Peptide Activates both Gs and Gi in Lung

S. MARTIN SHREEVE, MILES P. HACKER, DAVID E. GANNON, JOHN C. KERMODE

Journal:

Annals of the New York Academy of Sciences

Année:

1996

Langue:

english

Fichier:

PDF, 279 KB

english, 1996

24

Heterosubstituted anthracene-9,10-dione analogs. The synthesis and antitumor evaluation of 5,8-bis[(aminoalkyl)amino]naphtho[2,3-b]thiophene-4,9-diones

Krapcho, A. Paul, Petry, Mary E., Hacker, Miles P.

Journal:

Journal of Medicinal Chemistry

Année:

1990

Langue:

english

Fichier:

PDF, 724 KB

english, 1990

25

Potential DNA bis-intercalating agents: Synthesis and antitumor activity of novel, conformationally restricted bis(9-aminoacridines)

Gary D. Jaycox, Gordon W. Gribble, Miles P. Hacker

Journal:

Journal of Heterocyclic Chemistry

Année:

1987

Fichier:

PDF, 286 KB

1987

26

The synthesis of 6,9-bis[(aminoalkyl)amino] substituted benzo[g]quinoxaline-, benzo[g]quinazoline- and benzo-[g]phthalazine-5,10-diones via regiospecific displacements

A. Paul Krapcho, Martin J. Maresch, Anna L. Helgason, Kristin E. Rosner, Miles P. Hacker, Silvano Spinelli, Ernesto Menta, Ambrogio Oliva

Journal:

Journal of Heterocyclic Chemistry

Année:

1993

Fichier:

PDF, 786 KB

1993

27

The synthesis of 6,9-difluorobenzo[g]quinoline-5,10-dione. Displacements of the fluorides by diamines which lead to 6,9-bis[(aminoalkyl)amino]benzo[g]quinoline-5,10-diones

A. Paul Krapcho, Mary E. Petry, John J. Landi Jr., John Stallman, Johanna F. Polsenberg, Miles P. Hacker, Silvano Spinelli, Ambrogio Oliva, Roberto Di Domenico, Emesto Menta

Journal:

Journal of Heterocyclic Chemistry

Année:

1993

Fichier:

PDF, 366 KB

1993

28

Synthesis of 4-hydroxy-6,9-difluorobenz[g]isoquinoline-5,10-diones and conversions to 4-hydroxy-6,9-bis[(aminoalkyl)amino]-benz[g]isoquinoline-5,10-diones

A. Paul Krapcho, Martin J. Maresch, Cynthia E. Gallagher, Miles P. Hacker, Ernesto Menta, Ambrogio Oliva, Roberto Di Domenico, Giovanni Da Re, Silvano Spinelli

Journal:

Journal of Heterocyclic Chemistry

Année:

1995

Fichier:

PDF, 846 KB

1995

29

A study of science teaching processes and their implications for science education policy formation

R. G. Hacker, J. N. Miles

Journal:

Research in Science Education

Année:

1980

Langue:

english

Fichier:

PDF, 404 KB

english, 1980

30

Assessment of bleomycin-, tallysomycin-, and polyamine- mediated acute lung toxicity by pulmonary lavage angiotensin-converting enzyme activity

Robert A. Newman, Miles P. Hacker, Priscilla J. Kimberly, Joan M. Braddock

Journal:

Toxicology and Applied Pharmacology

Année:

1981

Langue:

english

Fichier:

PDF, 521 KB

english, 1981

31

Fibrogenic structure-activity study of the bleomycin molecule

Robert A. Newman, Miles P. Hacker, Ted T. Sakai

Journal:

Toxicology and Applied Pharmacology

Année:

1983

Langue:

english

Fichier:

PDF, 754 KB

english, 1983

32

The effect of l-3,4-dehydroproline on the antitumor activity and toxicity of bleomycin

Miles P. Hacker, Robert A. Newman, C.B. Hong

Journal:

Toxicology and Applied Pharmacology

Année:

1983

Langue:

english

Fichier:

PDF, 584 KB

english, 1983

33

Alteration of bronchoalveolar lavage cell populations following bleomycin treatment in mice

Diane Janick-Buckner, Gerald E. Ranges, Miles P. Hacker

Journal:

Toxicology and Applied Pharmacology

Année:

1989

Langue:

english

Fichier:

PDF, 768 KB

english, 1989

34

Effect of cytotoxic monoclonal antibody depletion of T-lymphocyte subpopulations on bleomycin-induced lung damage in C57BL/6J mice

Diane Janick-Buckner, Gerald E. Ranges, Miles P. Hacker

Journal:

Toxicology and Applied Pharmacology

Année:

1989

Langue:

english

Fichier:

PDF, 993 KB

english, 1989

35

Experimental tumors and aging: local factors that may account for the observed age advantage in the B16 murine melanoma model

William B. Ershler, Richard L. Gamelli, Ann L. Moore, Miles P. Hacker, Alton J. Blow

Journal:

Experimental Gerontology

Année:

1984

Langue:

english

Fichier:

PDF, 1.44 MB

english, 1984

36

A novel aza-anthrapyrazole blocks the progression of experimental autoimmune encephalomyelitis after the priming of autoimmunity

Alex Kiraly, Boyd Koffman, Miles Hacker, William Gunning, Sarah Rasche, Anthony Quinn

Journal:

Clinical Immunology

Année:

2011

Langue:

english

Fichier:

PDF, 1.38 MB

english, 2011

37

Impact of the basic amine on the biological activity and intracellular distribution of an aza-anthrapyrazole: BBR 3422

Kai-Ming Chou, A. Paul Krapcho, Miles P. Hacker

Journal:

Biochemical Pharmacology

Année:

2001

Langue:

english

Fichier:

PDF, 173 KB

english, 2001

38

Characterization of anthracenediones and their photoaffinity analogs

Kai-Ming Chou, A.Paul Krapcho, David Horn, Miles Hacker

Journal:

Biochemical Pharmacology

Année:

2002

Langue:

english

Fichier:

PDF, 128 KB

english, 2002

39

Anticholinesterase activity of the unsymmetric bisquaternary 6-aminoquinoline salt NSC-176319

Miles P. Hacker, Joan Braddock, Steven Unwin

Journal:

Biochemical Pharmacology

Année:

1982

Langue:

english

Fichier:

PDF, 396 KB

english, 1982

40

Adriamycin-mediated inhibition of creatine phosphokinase binding to heart mitochondrial membrane

Robert A. Newman, Miles P. Hacker, Mary Ann Fagan

Journal:

Biochemical Pharmacology

Année:

1982

Langue:

english

Fichier:

PDF, 397 KB

english, 1982

41

Activity of two novel anthracene-9,10-diones against human leukemia cells containing intercalator-sensitive or -resistant forms of topoisomerase II

Leonard A. Zwelling, Janice Mayes, Elizabeth Altschuler, Patricia Satitpunwaycha, Thomas R. Tritton, Miles P. Hacker

Journal:

Biochemical Pharmacology

Année:

1993

Langue:

english

Fichier:

PDF, 770 KB

english, 1993

42

Comparison of AZA-anthracenedione-induced DNA damage and cytotoxicity in experimental tumor cells

Lori A. Hazlehurst, A.Paul Krapcho, Miles P. Hacker

Journal:

Biochemical Pharmacology

Année:

1995

Langue:

english

Fichier:

PDF, 959 KB

english, 1995

43

Correlation of altered tyrosine phosphorylation with methotrexate resistance in a cisplatin-resistant subline of L1210 cells

Alok Bhushan, Diana Wroblewski, Yongzhi Xuan, Thomas R. Tritton, Miles P. Hacker

Journal:

Biochemical Pharmacology

Année:

1996

Langue:

english

Fichier:

PDF, 1009 KB

english, 1996

44

Characterization of lymphocyte activating factor from mouse tumor cell lines and human leukocytes

Lawrence B. Lachman, Gershwin T. Blyden, Miles Hacker, Robert E. Handschumacher

Journal:

Cellular Immunology

Année:

1976

Langue:

english

Fichier:

PDF, 100 KB

english, 1976

45

Preparation of lymphocyte-activating factor from continuous murine macrophage cell lines

Lawrence B. Lachman, Miles P. Hacker, Gershwin T. Blyden, Robert E. Handschumacher

Journal:

Cellular Immunology

Année:

1977

Langue:

english

Fichier:

PDF, 292 KB

english, 1977

46

Correlation of DNA reactivity and cytotoxicity of a new class of anticancer agents: Aza-anthracenediones

Lori A. Hazlehurst, A.Paul Krapcho, Miles P. Hacker

Journal:

Année:

1995

Langue:

english

Fichier:

PDF, 2.87 MB

english, 1995

47

Hypoxia Activated Prodrugs of a 9-Aza-anthrapyrazole Derivative That Has Promising Anticancer Activity

El-Dakdouki, Mohammad H., Adamski, Nicholas, Foster, Lecia, Hacker, Miles P., Erhardt, Paul W.

Journal:

Journal of Medicinal Chemistry

Année:

2011

Langue:

english

Fichier:

PDF, 194 KB

english, 2011

48

6,9-Bis[(aminoalkyl)amino]benzo[g]isoquinoline-5,10-diones. A Novel Class of Chromophore-Modified Antitumor Anthracene-9,10-diones: Synthesis and Antitumor Evaluations

Krapcho, A. Paul, Petry, Mary E., Getahun, Zelleka, Landi, John J., Stallman, John, Polsenberg, Johanna F., Gallagher, Cynthia E., Maresch, Martin J., Hacker, Miles P.

Journal:

Journal of Medicinal Chemistry

Année:

1994

Langue:

english

Fichier:

PDF, 1.52 MB

english, 1994

49

Cimetidine and the immune response: I. In vivo augmentation of nonspecific and specific immune response

William B. Ershler, Miles P. Hacker, Barbara J. Burroughs, L. Moore, Carl F. Myers

Journal:

Clinical Immunology and Immunopathology

Année:

1983

Langue:

english

Fichier:

PDF, 547 KB

english, 1983

50

Cytotoxicity and antitumor activity of bis(platinum) complexes. A novel class of platinum complexes active in cell lines resistant to both cisplatin and 1,2-diaminocyclohexane complexes

Farrell, Nicholas, Qu, Yun, Hacker, Miles P.

Journal:

Journal of Medicinal Chemistry

Année:

1990

Langue:

english

Fichier:

PDF, 807 KB

english, 1990